Anti Cardiolipin IgM GENLISA™ ELISA

Introduction: The systemic autoimmune disorder which causes recurrent vascular thrombosis and pregnancy losses is Anti-phospholipid syndrome (APS). The pathogenesis of APS is production of auto antibodies to phospholipid protein. Anti-phospholipid syndrome is detected either by a positive Anti-Cardiolipin antibody (aCL) or lupus anticoagulant test. APS may be either primary or secondary; when APS is present in patients without any underlying clinical illness it is primary. Secondary APS occurs in patients with systemic lupus erythematosus (SLE) or any other underlying autoimmune disease.
The symptoms are observed by disturbing balance between procoagulant and anticoagulant factors and disruption of the clotting mechanism by the antiphospholipid antibodies (APLA) leading to leg ulcers, toe gangrene, myocardial infarction, purpura, stroke, recurrent miscarriage or preterm births. The autoantibodies are present in 50% of patients with SLE and 1-5% of the general population. The antiphospholipid antibodies are found in serum in 1% of healthy persons and 3% of older age group. Though APS can involve in any age group, the target group is young to middle aged adults.